Dr. Ross Anna Laura, Head of Emerging Technologies, Research Prioritization and Support at WHO Geneva talking about the importance of using one health approach to promote biorisk research and mitigation in Africa. Uganda agreed to pilot the operationalization of the framework as a result of the regional workshop to operationalize the framework in the WHO African region held in Nairobi, Kenya from 24 to 25 January 2023. One important strategic activity of the action plan to pilot the framework in Uganda was the sensitization of relevant national stakeholders on its operationalization. In this regard, a 3-days national stakeholders’ workshop was held in Kampala, Uganda, from 21 to 23 November 2023, under the coordination of the Office of the Prime Minister with the support of the WHO Country Office in Uganda, the Regional Office for Africa, and WHO headquarters. The workshop's main goals were to present an overview of the framework and the pilot project; discuss an in-depth understanding of the current situation and existing biosafety and biosecurity activities, and dual-use research at the national level; and identify concrete applications of the framework to the Ugandan situation. During the workshop, a roadmap was developed for effective domestication and implementation of the framework. The workshop convened over 80 participants from diverse sectors representing human health, nonhuman animal health, plants and agriculture, environment, defense, security organizations, other developing and implementing partners as well as the Africa Centre for Disease Control and Prevention (Africa CDC), WHO Country Office for Uganda, Regional Office for Africa, and headquarters. The 3 days’ workshop was structured around a series of sessions that included presentations, panel discussions, working group discussions and plenary sessions to encouraged participation and active interactions. The workshop was inaugurated by the Director General of the Ministry of Health of Uganda alongside other opening remarks by representatives from WHO headquarters, WHO Country Office of Uganda and the Africa CDC.